Noda Lab
Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance
Kaitlyn Tsai, Vanja Stojković, Lianet Noda-Garcia, Iris D Young, Alexander G Myasnikov, Jordan Kleinman, Ali Palla, Stephen N Floor, Adam Frost, James S Fraser, Dan S Tawfik, Danica Galonić Fujimori
ELife Research Article (2022) PDF
Dan Salah Tawfik (1955–2021)
Longo, L.M., Despotović, D. & Noda-García L
Enzyme evolution in natural products biosynthesis: target- or diversity-oriented?
Noda-Garcia L & Tawfik D
Current Opinion in Chemical Biology (2020) PDF
Multiple Forms of Multifunctional Proteins in Health and Disease.
Espinosa-Cantú A, Cruz-Bonilla E, Noda-Garcia L & DeLuna A
Frontiers in Cell and Developmental Biology (2020) PDF
Chance and pleiotropy dominate genetic diversity in complex bacterial environments.
Noda-García L, Davidi D, Korenblum E, Elazar A, Putintseva E, Aharoni A & Tawfik DS
Nature Microbiology (2019) PDF
Metabolite–Enzyme Coevolution: From Single Enzymes to Metabolic Pathways and Networks.
Noda-Garcia L, Liebermeister W & Tawfik DS
Annual Review of Biochemistry (2018) PDF
The genetic basis for the adaptation of E. coli to sugar synthesis from CO2.
Herz E, Antonovsky N, Bar-On Y, Davidi D, Gleizer S, Prywes N, Noda-Garcia L, Lyn Frisch K, Zohar Y, Wernick DG, Savidor A, Barenholz U & Milo R
Nature Communications (2017) PDF
Bacilli glutamate dehydrogenases diverged via coevolution of transcription and enzyme regulation.
Noda-Garcia L, Romero Romero ML, Longo LM, Kolodkin‐Gal I & Tawfik DS
Native Mass Spectrometry of Recombinant Proteins from Crude Cell Lysates.
Gan J, Ben-Nissan G, Arkind G, Tarnavsky M, Trudeau D, Noda Garcia L, Tawfik DS & Sharon M
Analytical Chemistry (2017) PDF
Evolution of substrate specificity in a retained enzyme driven by gene loss.
Juárez-Vázquez AL, Edirisinghe JN, Verduzco-Castro EA, Michalska K, Wu C, Noda-García L, Babnigg G, Endres M, Medina-Ruíz S, Santoyo-Flores J, Carrillo-Tripp M, Ton-That H, Joachimiak A, Henry CS & Barona-Gómez F
Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.
Stojković V, Noda-Garcia L, Tawfik DS & Fujimori DG
Nucleic Acids Research (2016) PDF
Co-occurrence of analogous enzymes determines evolution of a novel (βα)8-isomerase sub-family after non-conserved mutations in flexible loop.
Verduzco-Castro EA, Michalska K, Endres M, Juárez-Vazquez AL, Noda-García L, Chang C, Henry CS, Babnigg G, Joachimiak A & Barona-Gómez F
Insights into the evolution of enzyme substrate promiscuity after the discovery of (βα)8 isomerase evolutionary intermediates from a diverse metagenome.
Noda-García L, Juárez-Vázquez AL, Ávila-Arcos MC, Verduzco-Castro EA, Montero-Morán G, Gaytán P, Carrillo-Tripp M & Barona-Gómez F
BMC Evolutionary Biology (2015) PDF
Enzyme evolution beyond gene duplication: A model for incorporating horizontal gene transfer.
Noda-García L & Barona-Gómez F
Mobile Genetic Elements (2013) PDF
Evolution of substrate specificity in a recipient’s enzyme following horizontal gene transfer.
Noda-García L, Camacho-Zarco AR, Medina-Ruíz S, Gaytán P, Carrillo-Tripp M, Fülöp V & Barona-Gómez F
Molecular Biology and Evolution (2013) PDF
What can genome-scale metabolic network reconstructions do for prokaryotic systematics?
Barona-Gómez F, Cruz-Morales P & Noda-García L
Antonie Van Leeuwenhoek (2012) PDF
Identification and analysis of residues contained on β → α loops of the dual-substrate (βα)8 phosphoribosyl isomerase a specific for its phosphoribosyl anthranilate isomerase activity.
Noda-García L, Camacho-Zarco AR, Verdel-Aranda K, Wright H, Soberón X, Fülöp V & Barona-Gómez F
The structure/function relationship of a dual-substrate (βα)8-isomerase.
Wright H, Noda-García L, Ochoa-Leyva A, Hodgson DA, Fülöp V & Barona-Gómez F
Biochemical and Biophysical Research Communications (2008) PDF